Visit Heikes original post with her emulsifier right here, LisaLise Pure Natural Skincare Mellieha, Malta, Heikes original post with her emulsifier right here. Optimizing the Drug Like properties of leads in drug discovery, biotechnology: Pharmaceutical aspects, vol. Journal of Food Measurement and Characterization Imagine that you can combine both hot and cold process emulsification in one single process. 61, 101284 (2021), S.A. Kulkarni, S.S. Feng, Pharm. My best mens moisturizer which has fantastic sensorials on the skin is based on Olivem+Emulprot. The great thing is: decorative cosmetics are so easy to make and don't cost much. Do you think Olivem 900 (sorbitan olivate on its own) should also be added first to water when using as a co emulsifier? PubMed Sucrose stearate belongs to the popular group of sucrose esters, a group of natural emulsifiers where sugar (sucrose) is esterified with a fatty acid from plant oils (stearic acid). Sorry to hijack the post, but what percentage did you use sucrose stearate for it to feel sticky? The live Q&A session is planned for 29th of March and I hope to meet (virtually) you during this Q&A and to answer your questions regarding the stability of your natural products. 2002;5:825. Pfizer BioN-Tech Bivalent COVID-19 Vaccine -12 years and older Code Description Effective Date MaineCare Rate 91312 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (coronavirus disease [COVID-19]) vaccine, mRNA-LNP, bivalent spike protein, preservative free, 30 mcg/0.3 mL dosage, tris-sucrose formulation, for intramuscular use Eldridge, E.A. Range of lipid phase: 10%-40% (usually 15%-25%), Usage concentrations: 1% (as a co-emulsifier), 2%-5% (as an emulsifier for gel creams and lotions), provides a protective barrier on the skin, improves hydration of the skin and reduces irritations, helps to soften the skin and smooths the skin's texture, forms light, gel-cream/lotion type, non-greasy emulsions, but also enables you to create medium viscosity and high viscosity emulsions and creams, no soapiness, no stickiness and no "rolling-off", exceptional skin feel, spreadability and absorbency, appropriate for a wide range of products (face, body and hair care). Learn how to become an organic skincare entrepreneur in our free masterclass. Need some inspiration for your cosmetic formulations? With the rise of environmental consciousness and the demand for sustainability as well as the industrial demand for time and energy saving procedures, it seems that these hot process emulsifiers, although still quite effective, are not necessarily as attractive as they used to be. Cold process sprayable emulsion with Sucrose Stearate 8(4), 206212 (2007), S. Agarwal, V. Bakshi, P. Vitta, A.P. PubMed Central Mellieha J Pharm Sci. 2023 Springer Nature Switzerland AG. Pudipeddi M, Zannou EA, Vasanthavada M, Dontabhaktuni A, Royce AE, Joshi YM, et al. I hope you'll enjoy working with "Sucrose Stearate" as much as I do. Tsosie, X. Xie, P. Li, J.B. Wan, C.W. Hydroxypropyl methylcellulose acetate succinate-based spray-dried dispersions: an overview. And now, with Heikes gracious permission, I am thrilled to present you with her formulation guide for this Sucragel-style emulsifier which I have named Sugar Ester Emulsifier. Your data is never shared or sold. She has over 20 years industry experience and is based in Bavaria, Germany. All cold process emulsifiers work in hot process as well but not all hot process emulsifiers work in a cold process or in a hot cold process emulsion. There are still thousands of emulsifiers that work this way and basically there is nothing wrong with them. Having now covered hot process emulsification as well as cold process emulsification, its time to look at hot cold process emulsification the process where the two meet in the middle. How to make a Hot Cold Process Emulsion - Formula Botanica It features ARGAN OIL and BEAUACTIVE. When you cold process Sucrose Stearate youre going to introduce lots of air into the emulsion if you do not first add the Xanthan Gum/Glycerin slurry. Pharm Res. 10(51), 3078530795 (2020), Article Gao P, Morozowich W. Development of supersaturable self-emulsifying drug delivery system formulations for improving oral absorption of poorly soluble drugs. 515, 543554 (2016), R. Sneha, B.N. Today, Im going to share a few cosmetics making secrets with you. Park, J. Nanomater. I'll soon be 60, and it's nice to be able to look rested and vital with few resources. The FTIR, XRD, and DSC analysis confirmed a successful encapsulation of curcumin. Ind. The great thing is that the emulsifier concentration in the final cosmetic product can be kept extremely low. *** Click on one of the three Forum categories below to start a new discussion ***, Home Cosmetic Science Talk Formulating Sucrose Stearate Cold Process Emulsion. 1999;16:18506. Homogenizing the two phases Step 4. The problematic excipients are best explained by the proton accepting capacity of excipient carboxylate groups which have pKas higher than the pHmax of the drug salt. For people who want for formulate cosmetics and get advice from other formulators around the world. 3. Second generation of drug nanocrystals for delivery of poorly soluble drugs: smartcrystals technology. Enhancement of stability and skin permeation by sucrose stearate and Pushpadass, L.N. 2000;44:23549. Cheng, F. Zhong, Food Hydrocoll. We try to respond to all messages within 2 working days, but are often much faster! 66(1), 222307 (2014), Article Heating the oil and water phase separately, Step 2. If you want to apply high concentrations of a heat sensitive ingredient, then a cold process emulsion or a hot cold process emulsion might be a better choice than a hot process emulsion. This Zemea Natural Skin Cream With Vanatural XGB features renewably sourced Zemea Propanediol, a multifunctional preservative-boosting humectant and solvent. 2005;109:47449. Solubility of doxycycline in aqueous solution. The excipients which induced measureable disproportionation were magnesium stearate, sodium croscarmellose, and sodium stearyl fumarate. As sucrose contains 8 hydroxy groups, compounds ranging from sucrose mono- to octa-fatty acid esters can be produced. Oat COM USP combats the symptoms of nappy rash and provides prolonged hydration, protection and soothes inflamed skin. With the rise of environmental consciousness and the demand for sustainability as well as the industrial demand for time and energy saving procedures, it seems that these hot process emulsifiers, although still quite effective, are not necessarily as attractive as they used to be. Am Pharm Rev. I've adjusted the pH by adding a few drops of 80% lactic acid to 5.45. As a current example: Olivem 900 is sorbitan olivate with an HLB of 4.7 and Olivem 1000 is cetearyl olivate (a wax which doesnt have an HLB value) and sorbitan olivate and yet, it has an HLB of 8-9. Can someone tell me what is causing this please? Meikle, Y. Su, X. Wang, C. Dekiwadia, C.J. Spectrosc. 25(3), 721727 (2016), Article What kind of products (and textures) can I make with sucrose stearate? Govindarajam R, Zinchuk A, Hancock B, Shalaev E, Suryanarayanan R. Ionization states in the microenvironment of solid dosage forms: effect of formulation variables and processing. I have been passing on my knowledge on Olionatura.de since 2006, in books since 2010 and in seminars and coaching sessions since 2015. You more or less INEVITABLY HAVE TO USE glycerol for d phase emulsification. Langmuir. 8- After the pH is adjusted, add the essential oils and blend shortly (a hand whisk or a glass rod is quite efficient for small volumes). I used to be use SS HLB 15 as a secondary emulsifier in the water phase, but to be honest I didnt like its sticky feeling. I normally add Glyceryl Oleate as a co-emulsifier for Sucrose Stearate for cold process formulas. The goal was to determine which excipients were problematic and correlate the results to known properties such as surface pH, slurry pH, or molecular structure. Mariya, M.E.E. Google Scholar. A formulation by Oat Cosmetics. Hot process usually creates stable emulsions with a small particle size. 2001; 2(4) article 28. El-Sawy, Drug Dev. And do you also always add dimethicone? 2006;23(10):245468. I did see an old post on this forum where someone said they always used it in the water phase and never got the soaping effect. As most of you may know, preparing sprayable emulsions is a tricky challenge. Part of Springer Nature. However I find the Olivem 1000 quite stable emulsifier, with exceptional ellectrolyte tolerance. Am Pharm Rev. You might have heard of a hot process emulsion. Sucrose stearate is used as an emulsifier in many beauty applications and cosmetics such as makeup products, cleansing formulas. The Well-Balanced Multivitamin: Geritol multivitamin is specially formulated with just the right vitamins in just the right amounts so you can feel your best! Formosinho, J. Merskio-Liversidge EM, Liversidge GG. J Pharm Sci. Please join me in welcoming the lovely and talented Heike Kser of Olionatura ! 2- Slowly add the water phase to the oil phase and blend the mixture (You can use a spatula, a glass rod or a magnetic stirrer for small quantities). Perera, J.M. Ha, S. Han, H. Kang, S.N. Add water phase using the same procedure as the oil phase. With Olivem 1000 is possible to make that so called water gel which is only Olivem + water. Guerrieri P, Taylor LS. Solid-state interaction of magnesium oxide and ibuprofen to form a salt. Serajuddin ATM, Thakur AB, Ghosal RN, Fakes MG, Ranadive SA, Morris KR, et al. Then add your oils phase and homogenize. Freshly boiled and cooled distilled water 44.0%, Freshly boiled and cooled distilled water 25.2%, Organic glycerine (we use 99.9% glycerine) 4.0%, 25% NaOH solution (a few drops to adjust the pH). Maurin MB, Grant DJW, Stahl PH. Kararli TT, Needham TE, Seul CJ, et al. When working with a cold process emulsifier, you usually need more physical agitation than compared to a hot process emulsifier. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. 13, 123133 (2001), R.M. Cantrell W, McCrory C, Ewing G. Nucleated deliquescence of salt. In: Borchardt R, editor. Add phase D to the emulsion and homogenize for a few seconds. Alas, most cosmetic emulsifiers are far from perfect D phase emulsification is therefore the closest one gets to adding it to the interphase. In: Stahl PH, Wermuth CG, editors. Correspondence to On top of that: I just love to learn :-) Pressing fresh oils, making extracts, distilling plants, conceiving new product ideas all this is creativity and sensuality in beautiful combination. J. Pharm. Development of sucrose stearate-based nanoemulsions and El-Say, J. Pharm. Drummond, C.E. and Transl. Adv Drug Deliv Rev. Tablet dissolution affected by a moisture mediated solid-state interaction between drug and disintegrant. Poor aqueous solubility - An industry wide problem in drug discovery. 1- Blend phase A and phase B in separate beakers @RT. Thermo Scientific Chemicals Sucrose stearate | Fisher Scientific Blend phases B and C separately in two other beakers. Preformulation in Solid Dosage Form Development, Informa Healthcare, 2008. The emulsions made with sucrose stearate are suitable for a spray, pump or dropper bottle if working with aqueous rheology modifiers or jar containers if working with fatty alcohols or other lipid hardeners. i left the coconut oil to stand at room temperature until it is completely liquid.. @ggpetrov I like olivem too, I find it makes stable and elegant emulsions, only setback is it cant be cold processed. Pharm. I wonder if they added it to the oil phase (as all the instructions for Olivem 1000 seem to recommend) and if it would have been better added in the water phase. Formulating with Sucrose Stearate: A must-have emulsifier in - LabNotes 2008;112:210915. Dr. Elham Eghbali was Formula Botanicas Cosmetic Chemist between 2014 and 2018. 2000;16:508692. Adsorption of water on solid surfaces studied by scanning force microscopy. The motivation for my research was and is a harmonious, sensible, physiological and resource-saving skin care. Fadda, Biomaterials 71, 100109 (2015), M.A. Akoh, Food Funct. Fernandez, M. Haring, C. Saldas, D. Daz Daz (2019) RSC Adv. 30, 25122522 (2013), V. Sharma, S. Anandhakumar, M. Sasidharan, Mater. Although this benefit is particularly significant when you are manufacturing at a large scale and producing large batches of lotion, it can still be an advantage even in your small artisanal lab (want to learn how to upscale your manufacturing and outsource to an external lab?). 1985;74:14854. Formulating with Sucragel: oleogel DOs & DON'Ts - LabNotes Skin Care: Transforming Comfort Mask by DSM. I won't tell you yet, quality takes time. Zannou EA, Ji Q, Joshi YM, Serajuddin ATM. Drug-like properties and the causes of poor solubility and poor permeability. Google Scholar. Usage instructions by suppliers are a lot of the time scarce and insufficient in order to know exactly how to create stable emulsions.
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